Aquaporins in brain: distribution, physiology, and pathophysiology.

On the Role of Aquaporins in Myocardial Injury

The presence of aquaporins in the cardiovascular system has been well documented, however our knowledge about their role in myocardial pathophysiology is now being elucidated. A brief overview of the presence, function and regulation of aquaporins in myocardial injury is here presented. On the Role of Aquaporins in Myocardial Injury Marcelo Ozu* Laboratorio de Biomembranas, Department of Physio...

Physiology And PAthoPhysiology of AquAPorins

Received 2 July 2010, accepted 1 August 2010. Correspondence to: Dr Amaia Rodríguez, Metabolic Research Laboratory, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain. Tel.: +34 948 42 56 00 (ext. 6544), Fax: +34 948 42 56 52, E-mail: [email protected] Abstract Aquaporins (AQPs) are water channels that facilitate a rapid transport of water, across cell membranes. in some cases, these pore...

Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.

The discovery of aquaporins by Agre and co-workers provided an answer to the long-standing biophysical question of how water can pass cell membranes. The identification and characterization of several aquaporins expressed in the kidney has allowed detailed insight, at the molecular level, into the fundamental physiology and pathophysiology of renal water metabolism.

Physiology and pathophysiology of aquaporins.

Aquaporins as targets for drug discovery.

The intracellular hydric balance is an essential process of mammalian cells. The water movement across cell membranes is driven by osmotic and hydrostatic forces and the speed of this process is dependent on the presence of specific aquaporin water channels. Since the molecular identification of the first water channel, AQP1, by Peter Agre's group, 13 homologous members have been found in mamma...